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Therefore, the effect of G6PD enzyme deficiency leading to NADPH insufficiency is particularly marked in the RBC

WilliamsLMGilmoreTD.Looking down on NF-B

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Genes repressed by wild-type p53, such as cyclin-dependent kinase 1 ( CDK1 ) , cyclin-A2 ( CCNA2 ), and cyclin B1/2 ( CCNB1/2 ), become aberrantly activated in the case of p53 mutations (R175H, R273H, and D281G), enabling cells to escape the control of cell proliferation and progress towards cancerous transformation